Clinical endocrinology · 2023
Standardising the biochemical confirmation of adult male hypogonadism: A joint position statement by the Society for Endocrinology and Association of Clinical Biochemistry and Laboratory Medicine.
СтатьяConsensus StatementНазвание и аннотация: Перевод пока не подготовлен
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Jayasena Channa N, de Silva Nipun L, O'Reilly Michael W, MacKenzie Finlay, Marrington Rachel, Jones Hugh, Livingston Mark, Downie Paul, Hackett Geoff, Ramachandran Sud, Tomlinson Jeremy, David Janine, Boot Christopher, Patel Mayur, Tarling Julie, Wu Fredrick, Quinton Richard
Аннотация
BACKGROUND: Inter-assay variation between different immunoassays and different mass spectrometry methods hampers the biochemical confirmation of male hypogonadism. Furthermore, some laboratories utilise assay manufacturer reference ranges that do not necessarily mirror assay performance characteristics, with the lower limit of normality ranging from 4.9 nmol/L to 11 nmol/L. The quality of the normative data underlying commercial immunoassay reference ranges is uncertain.
DESIGN: A working group reviewed published evidence and agreed upon standardised reporting guidance to augment total testosterone reports.
RESULTS: Evidence-based guidance on appropriate blood sampling, clinical action limits, and other major factors likely to affect the interpretation of results are provided.
CONCLUSIONS: This article aims to improve the quality of the interpretation of testosterone results by non-specialist clinicians. It also discusses approaches for assay harmonisation which have been successful in some but not all healthcare systems.
DESIGN: A working group reviewed published evidence and agreed upon standardised reporting guidance to augment total testosterone reports.
RESULTS: Evidence-based guidance on appropriate blood sampling, clinical action limits, and other major factors likely to affect the interpretation of results are provided.
CONCLUSIONS: This article aims to improve the quality of the interpretation of testosterone results by non-specialist clinicians. It also discusses approaches for assay harmonisation which have been successful in some but not all healthcare systems.