Bifonazole: patch-test trials on local tolerance.

Negative test reactions were obtained when 410 eczema patients (129 with allergic contact dermatitis) were tested using occlusion technique with bifonazole in yellow vaseline in the concentrations of 1, 4, 16 and 32%. The latter concentration is 32 times greater than the concentration used therapeutically. Thus bifonazole is not a primary irritant, when applied to the skin under occlusion, nor were any cross reactions observed with allergens previously known.