Human molecular genetics · 2014

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.

СтатьяМетаанализПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен

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He Meian, Xu Min, Zhang Ben, Liang Jun, Chen Peng, Lee Jong-Young, Johnson Todd A, Li Huaixing, Yang Xiaobo, Dai Juncheng, Liang Liming, Gui Lixuan, Qi Qibin, Huang Jinyan, Li Yanping, Adair Linda S, Aung Tin, Cai Qiuyin, Cheng Ching-Yu, Cho Myeong-Chan, Cho Yoon Shin, Chu Minjie, Cui Bin, Gao Yu-Tang, Go Min Jin, Gu Dongfeng, Gu Weiqiong, Guo Huan, Hao Yongchen, Hong Jie, Hu Zhibin, Hu Yanling, Huang Jianfeng, Hwang Joo-Yeon, Ikram Mohammad Kamran, Jin Guangfu, Kang Dae-Hee, Khor Chiea Chuen, Kim Bong-Jo, Kim Hung Tae, Kubo Michiaki, Lee Jeannette, Lee Juyoung, Lee Nanette R, Li Ruoying, Li Jun, Liu JianJun, Longe Jirong, Lu Wei, Lu Xiangfeng, Miao Xiaoping, Okada Yukinori, Ong Rick Twee-Hee, Qiu Gaokun, Seielstad Mark, Sim Xueling, Song Huaidong, Takeuchi Fumihiko, Tanaka Toshihiro, Taylor Phil R, Wang Laiyuan, Wang Weiqing, Wang Yiqin, Wu Chen, Wu Ying, Xiang Yong-Bing, Yamamoto Ken, Yang Handong, Liao Ming, Yokota Mitsuhiro, Young Terri, Zhang Xiaomin, Kato Norihiro, Wang Qing K, Zheng Wei, Hu Frank B, Lin Dongxin, Shen Hongbing, Teo Yik Ying, Mo Zengnan, Wong Tien Yin, Lin Xu, Mohlke Karen L, Ning Guang, Tsunoda Tatsuhiko, Han Bok-Ghee, Shu Xiao-Ou, Tai E Shyong, Wu Tangchun, Qi Lu

Аннотация

Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at P < 5 × 10(-8), together explaining 8.89% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5%) in Europeans, with comparable frequencies with in Asians, and 7 single-nucleotide polymorphisms are with low frequency (MAF < 5%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians.

Предметные рубрики MeSH

Adolescent Adult Aged Aged, 80 and over Asian People Body Height Asia, Eastern Female Gene Frequency Genetic Loci Genome-Wide Association Study Humans Male Metabolic Networks and Pathways Middle Aged Polymorphism, Single Nucleotide Protein Tyrosine Phosphatases White People Young Adult

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.

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Аннотация

Предметные рубрики MeSH