Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2005
Deer ked-induced occupational allergic rhinoconjunctivitis.
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Laukkanen Arja, Ruoppi Pirkko, Mäkinen-Kiljunen Soili
Аннотация
BACKGROUND: Deer keds (elk fly) have not previously been described as a cause of respiratory or conjunctival sensitization.
OBJECTIVE: To report a case of IgE-mediated allergic rhinoconjunctivitis from occupational exposure to deer ked.
METHODS: Skin prick testing (SPT) was performed with pollens, animal danders, mites, molds, and deer ked. The serum deer ked-specific IgE level was examined in ImmunoSpot and radioallergosorbent test assays, and deer ked IgE-binding fractions and their specificities were examined in immunoblot and immunoblot inhibition assays. Nasal provocation testing (NPT) and conjunctival provocation testing (CPT) were performed to detect the association between deer ked sensitization and rhinoconjunctival symptoms. Both SPT and NPT were performed with deer ked whole-body extract, whereas CPT was performed with deer ked wing.
RESULTS: The results of SPT, NPT, and CPT were positive for deer ked. In laboratory tests, serum deer ked-specific IgE antibodies were demonstrated in radioallergosorbent test and ImmunoSpot assays. In immunoblot, IgE-binding bands were demonstrated at 17, 33, 70, and 85 kDa, which were clearly inhibited with deer ked extract but not with the control extract.
CONCLUSIONS: Occupational IgE-mediated rhinoconjunctival allergy to deer ked was confirmed in this patient.
OBJECTIVE: To report a case of IgE-mediated allergic rhinoconjunctivitis from occupational exposure to deer ked.
METHODS: Skin prick testing (SPT) was performed with pollens, animal danders, mites, molds, and deer ked. The serum deer ked-specific IgE level was examined in ImmunoSpot and radioallergosorbent test assays, and deer ked IgE-binding fractions and their specificities were examined in immunoblot and immunoblot inhibition assays. Nasal provocation testing (NPT) and conjunctival provocation testing (CPT) were performed to detect the association between deer ked sensitization and rhinoconjunctival symptoms. Both SPT and NPT were performed with deer ked whole-body extract, whereas CPT was performed with deer ked wing.
RESULTS: The results of SPT, NPT, and CPT were positive for deer ked. In laboratory tests, serum deer ked-specific IgE antibodies were demonstrated in radioallergosorbent test and ImmunoSpot assays. In immunoblot, IgE-binding bands were demonstrated at 17, 33, 70, and 85 kDa, which were clearly inhibited with deer ked extract but not with the control extract.
CONCLUSIONS: Occupational IgE-mediated rhinoconjunctival allergy to deer ked was confirmed in this patient.