Response rate of initial conventional treatments, disease course, and related factors of patients with adult-onset Still's disease: Data from a large multicenter cohort.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Kalyoncu Umut, Solmaz Dilek, Emmungil Hakan, Yazici Ayten, Kasifoglu Timucin, Kimyon Gezmiş, Balkarli Ayşe, Bes Cemal, Ozmen Mustafa, Alibaz-Oner Fatma, Erten Sükran, Cagatay Yonca, Cetin Gözde Yıldırım, Yilmaz Sedat, Yildiz Fatih, Pamuk Omer Nuri, Kucuksahin Orhan, Kilic Levent, Yazisiz Veli, Karadag Omer, Koca Süleyman Serdar, Hayran Mutlu, Akar Servet, Aksu Kenan, Akkoc Nurullah, Keser Gokhan, Gonullu Emel, Kisacik Bunyamin, Onat Ahmet Mesut, Soy Mehmet, Inanc Nevsun, Direskeneli Haner, Sayarlioglu Mehmet, Erken Eren, Turgay Murat, Cefle Ayse, Ertenli Ihsan, Pay Salih
Аннотация
METHODS: A multicenter study was used to reach sufficient patient numbers. The diagnosis of AOSD was based on the Yamaguchi criteria. The data collected included patient age, gender, age at the time of diagnosis, delay time for the diagnosis, typical AOSD rash, arthralgia, arthritis, myalgia, sore throat, lymphadenopathy, hepatomegaly, splenomegaly, pleuritis, pericarditis, and other rare findings. The laboratory findings of the patients were also recorded. The drugs initiated after the establishment of a diagnosis and the induction of remission with the first treatment was recorded. Disease patterns and related factors were also investigated. A multivariate analysis was performed to assess the factors related to remission.
RESULTS: The initial data of 356 patients (210 females; 59%) from 19 centers were evaluated. The median age at onset was 32 (16-88) years, and the median follow-up time was 22 months (0-180). Fever (95.8%), arthralgia (94.9%), typical AOSD rash (66.9%), arthritis (64.6%), sore throat (63.5%), and myalgia (52.8%) were the most frequent clinical features. It was found that 254 of the 306 patients (83.0%) displayed remission with the initial treatment, including corticosteroids plus methotrexate with or without other disease-modifying antirheumatic drugs. The multivariate analysis revealed that the male sex, delayed diagnosis of more than 6 months, failure to achieve remission with initial treatment, and arthritis involving wrist/elbow joints were related to the chronic disease course.
CONCLUSION: Induction of remission with initial treatment was achieved in the majority of AOSD patients. Failure to achieve remission with initial treatment as well as a delayed diagnosis implicated a chronic disease course in AOSD.