Rationale and Study Design for an Individualized Perioperative Open Lung Ventilatory Strategy in Patients on One-Lung Ventilation (iPROVE-OLV).
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Carramiñana Albert, Ferrando Carlos, Unzueta M Carmen, Navarro Ricard, Suárez-Sipmann Fernando, Tusman Gerardo, Garutti Ignacio, Soro Marina, Pozo Natividad, Librero Julián, Gallego Lucía, Ramasco Fernando, Rabanal José M, Rodriguez Aurelio, Sastre José, Martinez Jesús, Coves Silvia, García Pablo, Aguirre-Puig Pilar, Yepes José, Lluch Aitana, López-Herrera Daniel, Leal Sonsoles, Vives Marc, Bellas Soledad, Socorro Tania, Trespalacios Ramón, Salazar Claudia J, Mugarra Ana, Cinnella Gilda, Spadaro Savino, Futier Emmanuel, Ferrer Leopoldo, Cabrera María, Ribeiro Helder, Celestino Catarina, Kucur Evrim, Cervantes Oriol, Morocho Diego, Delphy Dalia, Ramos Carolina, Villar Jesús, Belda Javier, iPROVE-OLV Network
Аннотация
DESIGN: International, multicenter, prospective, randomized controlled clinical trial.
SETTING: A network of university hospitals.
PARTICIPANTS: The study comprises 1,380 patients scheduled for thoracic surgery.
INTERVENTIONS: The individualized group will receive intraoperative recruitment maneuvers followed by individualized positive end-expiratory pressure (open lung approach) during the intraoperative period plus postoperative ventilatory support with high-flow nasal cannula, whereas the control group will be managed with conventional lung-protective ventilation.
MEASUREMENTS AND MAIN RESULTS: Individual and total number of postoperative complications, including atelectasis, pneumothorax, pleural effusion, pneumonia, acute lung injury; unplanned readmission and reintubation; length of stay and death in the critical care unit and in the hospital will be analyzed for both groups. The authors hypothesize that the intraoperative application of an open lung approach followed by an individual indication of high-flow nasal cannula in the postoperative period will reduce pulmonary complications and length of hospital stay in high-risk surgical patients.