Dynamic Hemodynamic Changes in Elderly Hypertensive Patients Undergoing Iopromide 370-Mediated Coronary CTA Examination: A Prospective Controlled Trial.

OBJECTIVE

Coronary computed tomography angiography (CTA) plays a pivotal role in the diagnosis of coronary heart disease in elderly hypertensive patients. This study aimed to investigate the hemodynamic changes in terms of dynamic characteristics, magnitude, and duration following intravenous bolus injection of iodinated contrast media.

METHODS

Thirty-two medicated hypertensive patients and 32 nonhypertensive patients underwent Iopromide 370-mediated coronary CTA examination (registration number: ChiCTR2300070704). Hemodynamic parameters were determined at 6 predefined time points from 1 minute before injection to 30 minutes postinjection, using a noninvasive hemodynamic monitoring system. Continuous variables were compared using an independent-samples t test. Categorical data were compared using the χ 2 test or a nonparametric test based on data distribution. Repeated measures data were analyzed using repeated measures analysis of variance.

RESULTS

The patterns of hemodynamic change were comparable between groups, with most indicators showing a transient increase followed by recovery to baseline. The magnitude of change was more pronounced in the hypertensive group, with most indicators fluctuating within 10% of baseline values. All hemodynamic values during injection correlated well with baseline levels in both groups, with Pearson correlation coefficients ranging from 0.61 to 0.87. No acute allergic-like reactions were observed, and there was no statistically significant difference in physiological responses between groups.

CONCLUSIONS

Our findings indicate that Iopromide 370 has favorable safety and tolerability. Greater clinical caution may be warranted for elderly hypertensive patients with cardiovascular comorbidities.