African health sciences · 2025
Incidence of acute kidney injury among high-risk adult patients undergoing iso-osmolar contrasted computed tomography scans: a prospective cohort study.
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Nakku Miriam, Muyinda Zeridah, Nabbosa Valeria, Mubuuke Aloysius G, Baluku Joseph B, Babirye Deborah, Walubembe Jonathan, Angom Diana O, Nalwoga Kevina, Kalyesubula Robert
Аннотация
BACKGROUND: The safety of iso-osmolar contrast media (IOCM) in patients at risk of contrast-induced kidney injury (CIAKI) is not well-established.
OBJECTIVE: To determine the incidence of CIAKI among high-risk adult patients undergoing iso-osmolar contrasted Computed Tomography (CT) scans.
METHODS: A prospective descriptive cohort study of patients at high risk of CIAKI was done. Questionnaires were used to collect clinical and examination findings. Blood samples were collected at baseline and at 48 hours post-administration of IOCM to assess changes in serum creatinine. Those found to have a ≥ 0.5mg/dl absolute increase in serum creatinine from the baseline within 48 hours of contrast administration were considered to have developed CIAKI. Pearson's Chi-square test was used to compare patients with and without CIAKI. Logistic regression models were used to determine associations of CIAKI.
RESULTS: The cumulative incidence of CIAKI was 9% (20/223), (95%CI - 5.8451-13.5215). No factors were independently associated with CIAKI in this study.
CONCLUSION: The incidence of CIAKI among high-risk adult patients undergoing CT scans was 9%. There were no factors significantly associated with CIAKI.
OBJECTIVE: To determine the incidence of CIAKI among high-risk adult patients undergoing iso-osmolar contrasted Computed Tomography (CT) scans.
METHODS: A prospective descriptive cohort study of patients at high risk of CIAKI was done. Questionnaires were used to collect clinical and examination findings. Blood samples were collected at baseline and at 48 hours post-administration of IOCM to assess changes in serum creatinine. Those found to have a ≥ 0.5mg/dl absolute increase in serum creatinine from the baseline within 48 hours of contrast administration were considered to have developed CIAKI. Pearson's Chi-square test was used to compare patients with and without CIAKI. Logistic regression models were used to determine associations of CIAKI.
RESULTS: The cumulative incidence of CIAKI was 9% (20/223), (95%CI - 5.8451-13.5215). No factors were independently associated with CIAKI in this study.
CONCLUSION: The incidence of CIAKI among high-risk adult patients undergoing CT scans was 9%. There were no factors significantly associated with CIAKI.