Immunity · 2013
Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Obermoser Gerlinde, Presnell Scott, Domico Kelly, Xu Hui, Wang Yuanyuan, Anguiano Esperanza, Thompson-Snipes Luann, Ranganathan Rajaram, Zeitner Brad, Bjork Anna, Anderson David, Speake Cate, Ruchaud Emily, Skinner Jason, Alsina Laia, Sharma Mamta, Dutartre Helene, Cepika Alma, Israelsson Elisabeth, Nguyen Phuong, Nguyen Quynh-Anh, Harrod A Carson, Zurawski Sandra M, Pascual Virginia, Ueno Hideki, Nepom Gerald T, Quinn Charlie, Blankenship Derek, Palucka Karolina, Banchereau Jacques, Chaussabel Damien
Аннотация
Systems immunology approaches were employed to investigate innate and adaptive immune responses to influenza and pneumococcal vaccines. These two non-live vaccines show different magnitudes of transcriptional responses at different time points after vaccination. Software solutions were developed to explore correlates of vaccine efficacy measured as antibody titers at day 28. These enabled a further dissection of transcriptional responses. Thus, the innate response, measured within hours in the peripheral blood, was dominated by an interferon transcriptional signature after influenza vaccination and by an inflammation signature after pneumococcal vaccination. Day 7 plasmablast responses induced by both vaccines was more pronounced after pneumococcal vaccination. Together, these results suggest that comparing global immune responses elicited by different vaccines will be critical to our understanding of the immune mechanisms underpinning successful vaccination.