Current and emerging treatment options for migraine and other primary headache disorders.

Primary headache disorders are highly prevalent worldwide. The impact of primary headaches to the individual is significant and reflects physical suffering and decreased social and occupational functioning. The economic burden to society is enormous and represents direct healthcare costs and the indirect costs associated with decreased workplace productivity and work absences. The last decade has witnessed tremendous advances both in our understanding of the biology of headache and in our therapeutic armamentarium. This review outlines how these developments may be rationally implemented by highlighting individual treatment options and general treatment strategies. The state-of-the-art methods for the abortive and prophylactic treatment of tension-type headache, migraine and cluster headache are reviewed.