The Role of MicroRNAs in Thrombosis.

MicroRNAs (miRNAs) are small noncoding regulatory RNA molecules that play a significant role in targeted downregulation of gene expression by RNA silencing and posttranscriptional regulation. Mounting evidence of recent studies indicates that there is dysregulation of expression level of a wide range of miRNAs in a variety of cardiovascular diseases related to thrombosis including venous thromboembolism, coronary artery disease, stroke, and myocardial infarction. In this review, the current knowledge on the role of miRNAs in thrombosis is discussed. Future research may further unravel the involvement of miRNAs in the pathogenesis of thrombosis as well as possibly clarify the clinical usefulness of miRNAs as biomarkers and potential therapeutic targets.