Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
Cognitive training and promoting a healthy lifestyle in isolated REM sleep behavior disorder: The randomized controlled trial CogTrAiL-RBD.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Ophey Anja, Röttgen Sinah, Kufer Konstantin, Pauquet Julia, Scharfenberg Daniel, Armbrust Philipp, Kammerzell Anastasia, Knopf Nathalie, Kollath Sandy, Sommer Philipp, Doppler Christopher E J, Farrher Ezequiel, Seger Aline, Shah N Jon, Zopfs David, Reetz Kathrin, Fink Gereon R, Sommerauer Michael, Kalbe Elke
Аннотация
INTRODUCTION: Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal phase of Lewy body diseases and linked to a high risk for cognitive decline. Therefore, iRBD provides a suitable window for early intervention.
METHODS: In the monocentric randomized controlled trial "Cognitive Training & a Healthy, Active Lifestyle Program for People with Isolated REM Sleep Behaviour Disorder" (CogTrAiL-RBD), the feasibility and behavioral effects of a 5-week digital, adaptive, multidomain cognitive training alongside a module promoting a healthy lifestyle (INT) were compared to a waiting-list control group (CON) in 82 individuals with polysomnography-confirmed iRBD. The primary outcome was change in executive functions at 6 weeks post-allocation (t1) and at 6-month follow-up (t2).
RESULTS: For executive functions, we found positive intervention effects for the INT versus CON with a medium effect at t1 (d = 0.500, 95% confidence interval [CI]: 0.221-0.779) and a small effect at t2 (d = 0.397, 95% CI: 0.115-0.679).
DISCUSSION: CogTrAiL-RBD provides initial evidence for the feasibility and potential cognitive benefits of cognitive training within a lifestyle-guidance framework in individuals with iRBD. Its suitability for dementia prevention warrants further investigation.
METHODS: In the monocentric randomized controlled trial "Cognitive Training & a Healthy, Active Lifestyle Program for People with Isolated REM Sleep Behaviour Disorder" (CogTrAiL-RBD), the feasibility and behavioral effects of a 5-week digital, adaptive, multidomain cognitive training alongside a module promoting a healthy lifestyle (INT) were compared to a waiting-list control group (CON) in 82 individuals with polysomnography-confirmed iRBD. The primary outcome was change in executive functions at 6 weeks post-allocation (t1) and at 6-month follow-up (t2).
RESULTS: For executive functions, we found positive intervention effects for the INT versus CON with a medium effect at t1 (d = 0.500, 95% confidence interval [CI]: 0.221-0.779) and a small effect at t2 (d = 0.397, 95% CI: 0.115-0.679).
DISCUSSION: CogTrAiL-RBD provides initial evidence for the feasibility and potential cognitive benefits of cognitive training within a lifestyle-guidance framework in individuals with iRBD. Its suitability for dementia prevention warrants further investigation.