Internal medicine (Tokyo, Japan) · 2021
Nivolumab-induced Vogt-Koyanagi-Harada-like Syndrome and Adrenocortical Insufficiency with Long-term Survival in a Patient with Non-small-cell Lung Cancer.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Ushio Ryota, Yamamoto Masaki, Miyasaka Atsushi, Muraoka Tatsuya, Kanaoka Hiromi, Tamura Hironori, Kaneko Ayami, Izawa Ami, Hirama Nobuyuki, Teranishi Shuhei, Manabe Saki, Inoue Tatsuya, Shibata Kunihiko, Sugiura Yasuyuki, Kudo Makoto, Kaneko Takeshi
Аннотация
A 58-year-old man was diagnosed with lung adenocarcinoma with a tumor proportion score of 10%. After six cycles of second-line chemotherapy with nivolumab, he achieved a complete response (CR) but developed uveitis and sensorineural hearing disorder, which were consistent with Vogt-Koyanagi-Harada (VKH)-like syndrome. Simultaneously, pituitary adrenocortical insufficiency was identified. Nivolumab discontinuation and systemic corticosteroid administration resolved these immune-related adverse events (irAEs). The patient has maintained a CR without any chemotherapy for approximately two years. We herein report a patient with a long-term progression-free survival despite chemotherapy discontinuation due to irAEs, including VKH-like syndrome, which were appropriately managed.