[Restatment. Mollaret's meningitis].

MOLLARET MENINGITIS Benign recurrent lymphocytic meningitis, also called Mollaret's Meningitis (MM), is a rare disease most commonly due to HSV-2 virus. Twenty to 30% of patients presenting a first meningitis due to HSV-2 will have recurrent meningitis. This pathology is characterized by recurrent attacks of sud-den onset meningitis with complete recovery, and intervals, free of any symptoms. The majority of patients do not report a history of genital herpes. The diagnosis is based on the clinic and analysis of the cerebrospinal fluid (CSF), which shows aseptic lymphocytic meningitis. A positive PCR for HSV-2 allows a diagnosis with certainty. Facing a negativ PCR, the diagnosis of MM is established after excluding other causes of recurrent lymphocytic meningitis. The pathophysiology is not well known but is linked to the reactivation of the HSV-2 virus located in the sacral ganglia of sensory neurons in a latent state after the primary genital infection. Treatment of a first episode of MM with HSV-2 is based on antivirals. But no treatment has been shown to be effective in reducing the duration of recurrences or the frequency of recurrences. The prognosis is excellent with a tendency to a spontaneous decrease of the frequency of recurrences over time. It is important to know this pathology, in order to avoid diagnostic wandering and the multiplication of invasive examinations.