Lung cancer (Amsterdam, Netherlands) · 2002
FDG-PET imaging and the diagnosis of non-small cell lung cancer in a region of high histoplasmosis prevalence.
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Croft Donita R, Trapp John, Kernstine Kemp, Kirchner Peter, Mullan Brian, Galvin Jeffery, Peterson Michael W, Gross Thomas, McLennan Geoffrey, Kern Jeffrey A
Аннотация
STUDY OBJECTIVE: Determine the sensitivity and specificity of [F-18]-fluorine-2-deoxy-D-glucose positron emission tomography (FDG-PET) in differentiating non-small cell lung cancer (NSCLC) from benign solitary pulmonary nodules (SPNs) in a region with a high endemic rate of histoplamosis.
DESIGN: Prospective, clinical study.
SETTING: University, tertiary referral hospital in the upper Mississippi River valley.
PATIENTS: Ninety patients with SPNs.
INTERVENTIONS: Independent interpretation of FDG-PET imaging, computed tomography and pathologic evaluation of the SPNs.
MEASUREMENTS AND RESULTS: To detect malignant SPNs, FDG-PET imaging had a sensitivity of 93%, a specificity of 40%, a positive predictive value (PPV) of 88% and a negative predictive value (NPV) of 55%.
CONCLUSIONS: In a region with a high prevalence of pulmonary fungal infection, FDG-PET is sensitive but has a low specificity and NPV for identifying NSCLC. In our study cohort, FDG-PET does not appear to reduce the need for SPN biopsies.
DESIGN: Prospective, clinical study.
SETTING: University, tertiary referral hospital in the upper Mississippi River valley.
PATIENTS: Ninety patients with SPNs.
INTERVENTIONS: Independent interpretation of FDG-PET imaging, computed tomography and pathologic evaluation of the SPNs.
MEASUREMENTS AND RESULTS: To detect malignant SPNs, FDG-PET imaging had a sensitivity of 93%, a specificity of 40%, a positive predictive value (PPV) of 88% and a negative predictive value (NPV) of 55%.
CONCLUSIONS: In a region with a high prevalence of pulmonary fungal infection, FDG-PET is sensitive but has a low specificity and NPV for identifying NSCLC. In our study cohort, FDG-PET does not appear to reduce the need for SPN biopsies.
Предметные рубрики MeSH
AdultAgedAged, 80 and overCarcinoma, Non-Small-Cell LungDiagnosis, DifferentialFemaleFluorodeoxyglucose F18HistoplasmosisHumansIowaLung NeoplasmsMaleMiddle AgedPredictive Value of TestsPrevalenceProspective StudiesRadiopharmaceuticalsSensitivity and SpecificityTomography, Emission-ComputedTomography, X-Ray Computed