Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk.
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Hohman Timothy J, Cooke-Bailey Jessica N, Reitz Christiane, Jun Gyungah, Naj Adam, Beecham Gary W, Liu Zhi, Carney Regina M, Vance Jeffrey M, Cuccaro Michael L, Rajbhandary Ruchita, Vardarajan Badri Narayan, Wang Li-San, Valladares Otto, Lin Chiao-Feng, Larson Eric B, Graff-Radford Neill R, Evans Denis, De Jager Philip L, Crane Paul K, Buxbaum Joseph D, Murrell Jill R, Raj Towfique, Ertekin-Taner Nilufer, Logue Mark W, Baldwin Clinton T, Green Robert C, Barnes Lisa L, Cantwell Laura B, Fallin M Daniele, Go Rodney C P, Griffith Patrick, Obisesan Thomas O, Manly Jennifer J, Lunetta Kathryn L, Kamboh M Ilyas, Lopez Oscar L, Bennett David A, Hardy John, Hendrie Hugh C, Hall Kathleen S, Goate Alison M, Lang Rosalyn, Byrd Goldie S, Kukull Walter A, Foroud Tatiana M, Farrer Lindsay A, Martin Eden R, Pericak-Vance Margaret A, Schellenberg Gerard D, Mayeux Richard, Haines Jonathan L, Thornton-Wells Tricia A, Alzheimer Disease Genetics Consortium
Аннотация
METHODS: We performed a comprehensive analysis of genetically determined local and global ancestry in AAs with regard to LOAD status.
RESULTS: Compared to controls, LOAD cases showed higher levels of African ancestry, both globally and at several LOAD relevant loci, which explained risk for AD beyond global differences.
DISCUSSION: Exploratory post hoc analyses highlight regions with greatest differences in ancestry as potential candidate regions for future genetic analyses.