Neurobiology of aging · 2014
7T T₂*-weighted magnetic resonance imaging reveals cortical phase differences between early- and late-onset Alzheimer's disease.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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van Rooden Sanneke, Doan Nhat Trung, Versluis Maarten J, Goos Jeroen D C, Webb Andrew G, Oleksik Ania M, van der Flier Wiesje M, Scheltens Philip, Barkhof Frederik, Weverling-Rynsburger Annelies W E, Blauw Gerard Jan, Reiber Johan H C, van Buchem Mark A, Milles Julien, van der Grond Jeroen
Аннотация
The aim of this study is to explore regional iron-related differences in the cerebral cortex, indicative of Alzheimer's disease pathology, between early- and late-onset Alzheimer's disease (EOAD, LOAD, respectively) patients using 7T magnetic resonance phase images. High-resolution T2(∗)-weighted scans were acquired in 12 EOAD patients and 17 LOAD patients with mild to moderate disease and 27 healthy elderly control subjects. Lobar peak-to-peak phase shifts and regional mean phase contrasts were computed. An increased peak-to-peak phase shift was found for all lobar regions in EOAD patients compared with LOAD patients (p < 0.05). Regional mean phase contrast in EOAD patients was higher than in LOAD patients in the superior medial and middle frontal gyrus, anterior and middle cingulate gyrus, postcentral gyrus, superior and inferior parietal gyrus, and precuneus (p ≤ 0.042). These data suggest that EOAD patients have an increased iron accumulation, possibly related to an increased amyloid deposition, in specific cortical regions as compared with LOAD patients.