Gan to kagaku ryoho. Cancer & chemotherapy · 2013
[A case of gastric adenosquamous carcinoma producing granulocyte-colony stimulating factor].
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Saito Hiroto, Oyama Katsunobu, Fushida Sachio, Tsukada Tomoya, Okamoto Kouichi, Nakanuma Nobukazu, Kinoshita Jun, Makino Isamu, Nakamura Keishi, Hayashi Hironori, Inokuchi Masafumi, Nakagawara Hisatoshi, Miyashita Tomoharu, Fujita Hideto, Tajima Hidehiro, Takamura Hiroyuki, Ninomiya Itasu, Kitagawa Hirohisa, Fujimura Takashi, Ohta Tetsuo
Аннотация
We report a case of gastric adenosquamous carcinoma producing granulocyte-colony stimulating factor (G-CSF). A 60- year-old man was admitted to our hospital complaining of upper abdominal pain. Endoscopic examination revealed a large type 5 advanced gastric cancer with bleeding from the low body of stomach to the antrum, accompanied with para-aortic and mesenteric lymph node metastasis. He had marked leukocytosis, and serum levels of G-CSF were elevated. Histological diagnosis of the biopsy specimen was adenosquamous carcinoma producing G-CSF. We attempted combination chemotherapy with docetaxel, cisplatin and S-1(DCS). After 1 course of treatment, the primary lesion was reduced in size. However, the size of the metastatic lymph node was larger. Chemotherapy was not effective enough, and the patient died 3 months after ending chemotherapy.