Generation of an induced pluripotent stem cell line (NIMHi28-A) from a parkinsonian-type multiple system atrophy patient of Indian origin.

Multiple System Atrophy (MSA) is a rare, adult-onset, and rapidly progressive neurodegenerative disorder characterized by motor dysfunction and autonomic failure, with an estimated prevalence of 1.9-4.9 per 100,000 individuals per year. Clinically, MSA is broadly classified into two major phenotypes: cerebellar-dominant (MSA-C) and Parkinsonian-dominant (MSA-P). In this study, induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells of a clinically diagnosed MSA-P patient using Sendai virus-mediated reprogramming. Detailed characterization demonstrated robust self-renewal capacity and expression of key markers associated with the undifferentiated pluripotent state. This iPSC line represents a valuable biological resource for modelling disease mechanisms in patient-derived cell types and provides a promising platform for biomarker identification and therapeutic drug screening.