A Selectfluor-based Polonovski Rearrangement Leading to Novel Entities for Synthetic and Medicinal Applications.

The classical Polonovski reaction starting from N-oxides of tertiary amines and acid chlorides, or anhydrides, offers manifold synthetic options. This large preparative potential is now broadened by a novel, unusual version of the Polonovski reaction based on Selectfluor and carboxylic acids, through which new chemical entities for synthetic and medicinal applications become readily accessible under particularly mild conditions.