Respirology case reports · 2025
A Case of Syndrome of Inappropriate Secretion of Antidiuretic Hormone Induced by Selpercatinib in a Patient With RET Fusion Gene-Positive Non-Small Cell Lung Cancer.
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Tanaka Yuma, Ikegami Naoya, Miyamoto Kodai, Shingu Yusuke, Okagaki Nobuhiro, Sakamoto Hiroto, Nakanishi Tsukasa, Nakamura Satoshi, Matsumura Kazuki, Ueyama Masakuni, Kaji Yusuke, Hashimoto Seishu, Tanaka Eisaku, Taguchi Yoshio, Ohsumi Yuki, Nakagawa Tatsuo, Matsunaga Satoshi, Hajiro Takashi
Аннотация
An 80-year-old woman with a lung nodule in the right lower lobe and pleural thickening was diagnosed with lung adenocarcinoma by a surgical lung biopsy. The oncogene panel test showed a positive RET-fusion gene mutation, and selpercatinib was administered as a first-line treatment. She developed severe hyponatremia and was subsequently diagnosed with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Discontinuing selpercatinib and initiating demethyltetracycline gradually improved SIADH. After confirming that sodium levels had returned to normal, we resumed and continued selpercatinib at a reduced dose without a recurrence of SIADH. This case suggests that selpercatinib could cause SIADH as an adverse event.