Health science reports · 2026
Abdominal Obesity Phenotypes and Incidence of Type 2 DM, Cardiovascular Outcomes and All-Cause Mortality-A Systematic Review and Meta-Analysis.
СтатьяОбзорНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Doustmohamadian Soraya, Momeni Marjan, Mirmohammadkhani Majid, Doustmohammadian Azam, Hosseinpanah Farhad
Аннотация
BACKGROUND AND AIMS: The global rise in obesity, a major driver of metabolic diseases, has prompted scrutiny of distinct obesity phenotypes. While overall obesity is concerning, abdominal obesity demonstrates a stronger association with metabolic dysfunction, type 2 diabetes (DM2), and cardiovascular disease (CVD). This review examines the risk of DM2, CVD, and mortality in adults with a metabolically healthy abdominal obese phenotype.
METHODS: A systematic search of PubMed/MEDLINE, Web of Science, Cochrane Library, and ProQuest was conducted on April 7, 2025, to identify prospective cohort studies in adults. Eligible studies compared MHAO individuals to metabolically healthy, non-abdominally obese (MHNAO) controls, focusing on outcomes including incident T2DM, fatal and non-fatal CVD events, and all-cause mortality. Pooled estimates were calculated using random-effects meta-analysis, and heterogeneity was assessed using the I² statistic.
RESULTS: Six prospective cohort studies (n = 98,329) were included. Metabolically unhealthy individuals, regardless of abdominal obesity status, had significantly increased risks of T2DM (RR 9.00, 95% CI 7.51-10.50 for MUHAO; RR 5.03, 95% CI 4.11-5.94 for MUHNAO), CVD, and all-cause mortality (HR 1.67, 95% CI 1.42-1.93 for MUHAO; HR 1.58, 95% CI 1.36-1.79 for MUHNAO). In contrast, MHAO individuals did not show significantly elevated risks of T2DM (RR 2.44, 95% CI 0.95-3.94), CVD, or all-cause mortality (HR 1.07, 95% CI 0.88-1.27) compared to MHNAO controls. Substantial heterogeneity (I² > 50%) was observed, partly explained by differences in outcome definitions and metabolic classifications.
CONCLUSION: While metabolically unhealthy phenotypes are strongly associated with adverse health outcomes, individuals with MHAO appear to have risk profiles comparable to their metabolically healthy, non-abdominally obese counterparts. Nevertheless, abdominal adiposity and metabolic status remain critical determinants of long-term health, and the MHAO phenotype may not be entirely benign. Trial Registration: PROSPERO (CRD42019111056).
METHODS: A systematic search of PubMed/MEDLINE, Web of Science, Cochrane Library, and ProQuest was conducted on April 7, 2025, to identify prospective cohort studies in adults. Eligible studies compared MHAO individuals to metabolically healthy, non-abdominally obese (MHNAO) controls, focusing on outcomes including incident T2DM, fatal and non-fatal CVD events, and all-cause mortality. Pooled estimates were calculated using random-effects meta-analysis, and heterogeneity was assessed using the I² statistic.
RESULTS: Six prospective cohort studies (n = 98,329) were included. Metabolically unhealthy individuals, regardless of abdominal obesity status, had significantly increased risks of T2DM (RR 9.00, 95% CI 7.51-10.50 for MUHAO; RR 5.03, 95% CI 4.11-5.94 for MUHNAO), CVD, and all-cause mortality (HR 1.67, 95% CI 1.42-1.93 for MUHAO; HR 1.58, 95% CI 1.36-1.79 for MUHNAO). In contrast, MHAO individuals did not show significantly elevated risks of T2DM (RR 2.44, 95% CI 0.95-3.94), CVD, or all-cause mortality (HR 1.07, 95% CI 0.88-1.27) compared to MHNAO controls. Substantial heterogeneity (I² > 50%) was observed, partly explained by differences in outcome definitions and metabolic classifications.
CONCLUSION: While metabolically unhealthy phenotypes are strongly associated with adverse health outcomes, individuals with MHAO appear to have risk profiles comparable to their metabolically healthy, non-abdominally obese counterparts. Nevertheless, abdominal adiposity and metabolic status remain critical determinants of long-term health, and the MHAO phenotype may not be entirely benign. Trial Registration: PROSPERO (CRD42019111056).