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DOI 10.1016/j.dadm.2018.08.012

Медицинская библиотека · Alzheimer's & dementia (Amsterdam, Netherlands) · 2018

Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease.

Joseph-Mathurin Nelly, Su Yi, Blazey Tyler M, Jasielec Mateusz, Vlassenko Andrei, Friedrichsen Karl, Gordon Brian A, Hornbeck Russ C, Cash Lisa, Ances Beau M, Veale Thomas, Cash David M, Brickman Adam M, Buckles Virginia, Cairns Nigel J, Cruchaga Carlos, Goate Alison, Jack Clifford R, Karch Celeste, Klunk William, Koeppe Robert A, Marcus Daniel S, Mayeux Richard, McDade Eric, Noble James M, Ringman John, Saykin Andrew J, Thompson Paul M, Xiong Chengjie, Morris John C, Bateman Randall J, Benzinger Tammie L S, Dominantly Inherited Alzheimer Network

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Аннотация

INTRODUCTION

18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is commonly used to estimate neuronal injury in Alzheimer's disease (AD). Here, we evaluate the utility of dynamic PET measures of perfusion using 11C-Pittsburgh compound B (PiB) to estimate neuronal injury in comparison to FDG PET.

METHODS

FDG, early frames of PiB images, and relative PiB delivery rate constants (PiB-R1) were obtained from 110 participants from the Dominantly Inherited Alzheimer Network. Voxelwise, regional cross-sectional, and longitudinal analyses were done to evaluate the correlation between images and estimate the relationship of the imaging biomarkers with estimated time to disease progression based on family history.

RESULTS

Metabolism and perfusion images were spatially correlated. Regional PiB-R1 values and FDG, but not early frames of PiB images, significantly decreased in the mutation carriers with estimated year to onset and with increasing dementia severity.

DISCUSSION: Hypometabolism estimated by PiB-R1 may provide a measure of brain perfusion without increasing radiation exposure.

Для цитирования: Joseph-Mathurin Nelly, Su Yi, Blazey Tyler M, Jasielec Mateusz, Vlassenko Andrei, Friedrichsen Karl, Gordon Brian A, Hornbeck Russ C, Cash Lisa, Ances Beau M, Veale Thomas, Cash David M, Brickman Adam M, Buckles Virginia, Cairns Nigel J, Cruchaga Carlos, Goate Alison, Jack Clifford R, Karch Celeste, Klunk William, Koeppe Robert A, Marcus Daniel S, Mayeux Richard, McDade Eric, Noble James M, Ringman John, Saykin Andrew J, Thompson Paul M, Xiong Chengjie, Morris John C, Bateman Randall J, Benzinger Tammie L S, Dominantly Inherited Alzheimer Network. Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease.. Alzheimer's & dementia (Amsterdam, Netherlands). 2018. DOI: 10.1016/j.dadm.2018.08.012.
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