The impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease: A European Alzheimer's Disease Consortium study.
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Bosco Paolo, Redolfi Alberto, Bocchetta Martina, Ferrari Clarissa, Mega Anna, Galluzzi Samantha, Austin Mark, Chincarini Andrea, Collins D Louis, Duchesne Simon, Maréchal Bénédicte, Roche Alexis, Sensi Francesco, Wolz Robin, Alegret Montserrat, Assal Frederic, Balasa Mircea, Bastin Christine, Bougea Anastasia, Emek-Savaş Derya Durusu, Engelborghs Sebastiaan, Grimmer Timo, Grosu Galina, Kramberger Milica G, Lawlor Brian, Mandic Stojmenovic Gorana, Marinescu Mihaela, Mecocci Patrizia, Molinuevo José Luis, Morais Ricardo, Niemantsverdriet Ellis, Nobili Flavio, Ntovas Konstantinos, O'Dwyer Sarah, Paraskevas George P, Pelini Luca, Picco Agnese, Salmon Eric, Santana Isabel, Sotolongo-Grau Oscar, Spiru Luiza, Stefanova Elka, Popovic Katarina Surlan, Tsolaki Magda, Yener Görsev G, Zekry Dina, Frisoni Giovanni B
Аннотация
METHODS: Three hundred fifty-six patients, under clinical evaluation for cognitive impairment, with suspected AD and Mini-Mental State Examination ≥20, were recruited across 17 European memory clinics. After the traditional diagnostic workup, diagnostic confidence of AD pathology (DCAD) was estimated by the physicians in charge. The latter were provided with the results of automated hippocampal volumetry in standardized format and DCAD was reassessed.
RESULTS: An increment of one interquartile range in hippocampal volume was associated with a mean change of DCAD of -8.0% (95% credible interval: [-11.5, -5.0]). Automated hippocampal volumetry showed a statistically significant impact on DCAD beyond the contributions of neuropsychology, 18F-fluorodeoxyglucose positron emission tomography/single-photon emission computed tomography, and cerebrospinal fluid markers (-8.5, CrI: [-11.5, -5.6]; -14.1, CrI: [-19.3, -8.8]; -10.6, CrI: [-14.6, -6.1], respectively).
DISCUSSION: There is a measurable effect of hippocampal volume on DCAD even when used on top of the traditional diagnostic workup.