Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Triggered by Heat Stroke: A Case Report.

We present the first documented case of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) triggered by heat stroke in a man in his mid-50s with no medical history. After experiencing acute symptoms during a heatwave, he was hospitalized. The absence of dehydration and the presence of hyponatremia, along with other laboratory findings, fulfilled the diagnostic criteria for SIADH once other causes were excluded. The linkage between heat stroke and SIADH is thought to involve neuroinflammation and oxidative stress in the hypothalamus, which impacts antidiuretic hormone (ADH) production and secretion. This case highlights critical considerations for emergency and post-acute care in heat-related illnesses, emphasizing the need for vigilant monitoring of SIADH symptoms in patients experiencing heat stroke.