Psychiatria Hungarica : A Magyar Pszichiatriai Tarsasag tudomanyos folyoirata · 2010
[Gamma oscillation synchronization in schizophrenia--literature review].
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Papp Szilvia, Tombor László, Komlósi Sarolta, Balogh Lívia, Simon Viktória, Czobor Pál
Аннотация
INTRODUCTION: Gamma oscillation - as a basic operating mode of cortical networks - has received considerable interest in the the current EEG literature. Research in the field of gamma synchronization in schizophrenia has become the focus of psychiatry research in the past two decades, obtaining significant attention from the beginning, since the idea that a deficit in synchronization, especially in gamma oscillation synchronization might play a principal role in certain schizophrenia symptoms has emerged.
METHODS: In our review we aim to provide a brief description of the theoretical background, as well as an overview of differences in gamma oscillation synchronization observed in patients with schizophrenia compared to healthy controls. In order to identify relevant articles, we used PubMed and Medline search engines. For the current paper we reviewed articles published between 1999-2009, which reported results of clinical studies.
RESULTS: Consistent evidence for gamma synchronization deficit in both visual and acoustic modalities has been found in patients with schizophrenia as compared to healthy controls from most of the available studies, but the methodological heterogeneity observable in the field make the generalization of findings difficult.
CONCLUSIONS: The alteration observed in gamma oscillations and synchrony in patients with schizophrenia might play an important role in the pathophysiology of the disease. The potential relevance of the topic with regard to clinical practice underlines the need for more research.
METHODS: In our review we aim to provide a brief description of the theoretical background, as well as an overview of differences in gamma oscillation synchronization observed in patients with schizophrenia compared to healthy controls. In order to identify relevant articles, we used PubMed and Medline search engines. For the current paper we reviewed articles published between 1999-2009, which reported results of clinical studies.
RESULTS: Consistent evidence for gamma synchronization deficit in both visual and acoustic modalities has been found in patients with schizophrenia as compared to healthy controls from most of the available studies, but the methodological heterogeneity observable in the field make the generalization of findings difficult.
CONCLUSIONS: The alteration observed in gamma oscillations and synchrony in patients with schizophrenia might play an important role in the pathophysiology of the disease. The potential relevance of the topic with regard to clinical practice underlines the need for more research.