Frequency of Borrelia in Morphea Lesion by Polymerase Chain Reaction in Northeast of Iran.

BACKGROUND

The etiology of morphea is still unknown. Borrelia spp. as a causative agent of morphea has been discussed since 1985, but the relationship remains uncertain.

OBJECTIVES

We aimed to find the frequency of Borrelia in morphea lesions by polymerase chain reaction (PCR) in northeast of Iran.

PATIENTS AND

METHODS

Sixty six patients with morphea were prospectively included in the present study. For each patient, formalin-fixed, paraffin-embedded tissue blocks of skin lesion biopsies were examined for Borrelia spp. DNA using PCR.

RESULTS

No Borrelia DNA was detected by PCR in skin lesions of patients with morphea.

CONCLUSIONS

The result of this study showed no relationship between Borrelia infection and morphea lesions and in other word indicated that morphea, at least in Iran, is not caused by Borrelia spp.