Genome-wide meta-analysis identifies new susceptibility loci for migraine.
Anttila Verneri, Winsvold Bendik S, Gormley Padhraig, Kurth Tobias, Bettella Francesco, McMahon George, Kallela Mikko, Malik Rainer, de Vries Boukje, Terwindt Gisela, Medland Sarah E, Todt Unda, McArdle Wendy L, Quaye Lydia, Koiranen Markku, Ikram M Arfan, Lehtimäki Terho, Stam Anine H, Ligthart Lannie, Wedenoja Juho, Dunham Ian, Neale Benjamin M, Palta Priit, Hamalainen Eija, Schürks Markus, Rose Lynda M, Buring Julie E, Ridker Paul M, Steinberg Stacy, Stefansson Hreinn, Jakobsson Finnbogi, Lawlor Debbie A, Evans David M, Ring Susan M, Färkkilä Markus, Artto Ville, Kaunisto Mari A, Freilinger Tobias, Schoenen Jean, Frants Rune R, Pelzer Nadine, Weller Claudia M, Zielman Ronald, Heath Andrew C, Madden Pamela A F, Montgomery Grant W, Martin Nicholas G, Borck Guntram, Göbel Hartmut, Heinze Axel, Heinze-Kuhn Katja, Williams Frances M K, Hartikainen Anna-Liisa, Pouta Anneli, van den Ende Joyce, Uitterlinden Andre G, Hofman Albert, Amin Najaf, Hottenga Jouke-Jan, Vink Jacqueline M, Heikkilä Kauko, Alexander Michael, Muller-Myhsok Bertram, Schreiber Stefan, Meitinger Thomas, Wichmann Heinz Erich, Aromaa Arpo, Eriksson Johan G, Traynor Bryan, Trabzuni Daniah, North American Brain Expression Consortium, UK Brain Expression Consortium, Rossin Elizabeth, Lage Kasper, Jacobs Suzanne B R, Gibbs J Raphael, Birney Ewan, Kaprio Jaakko, Penninx Brenda W, Boomsma Dorret I, van Duijn Cornelia, Raitakari Olli, Jarvelin Marjo-Riitta, Zwart John-Anker, Cherkas Lynn, Strachan David P, Kubisch Christian, Ferrari Michel D, van den Maagdenberg Arn M J M, Dichgans Martin, Wessman Maija, Smith George Davey, Stefansson Kari, Daly Mark J, Nyholt Dale R, Chasman Daniel, Palotie Aarno
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Аннотация
Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P<5×10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.
Для цитирования: Anttila Verneri, Winsvold Bendik S, Gormley Padhraig, Kurth Tobias, Bettella Francesco, McMahon George, Kallela Mikko, Malik Rainer, de Vries Boukje, Terwindt Gisela, Medland Sarah E, Todt Unda, McArdle Wendy L, Quaye Lydia, Koiranen Markku, Ikram M Arfan, Lehtimäki Terho, Stam Anine H, Ligthart Lannie, Wedenoja Juho, Dunham Ian, Neale Benjamin M, Palta Priit, Hamalainen Eija, Schürks Markus, Rose Lynda M, Buring Julie E, Ridker Paul M, Steinberg Stacy, Stefansson Hreinn, Jakobsson Finnbogi, Lawlor Debbie A, Evans David M, Ring Susan M, Färkkilä Markus, Artto Ville, Kaunisto Mari A, Freilinger Tobias, Schoenen Jean, Frants Rune R, Pelzer Nadine, Weller Claudia M, Zielman Ronald, Heath Andrew C, Madden Pamela A F, Montgomery Grant W, Martin Nicholas G, Borck Guntram, Göbel Hartmut, Heinze Axel, Heinze-Kuhn Katja, Williams Frances M K, Hartikainen Anna-Liisa, Pouta Anneli, van den Ende Joyce, Uitterlinden Andre G, Hofman Albert, Amin Najaf, Hottenga Jouke-Jan, Vink Jacqueline M, Heikkilä Kauko, Alexander Michael, Muller-Myhsok Bertram, Schreiber Stefan, Meitinger Thomas, Wichmann Heinz Erich, Aromaa Arpo, Eriksson Johan G, Traynor Bryan, Trabzuni Daniah, North American Brain Expression Consortium, UK Brain Expression Consortium, Rossin Elizabeth, Lage Kasper, Jacobs Suzanne B R, Gibbs J Raphael, Birney Ewan, Kaprio Jaakko, Penninx Brenda W, Boomsma Dorret I, van Duijn Cornelia, Raitakari Olli, Jarvelin Marjo-Riitta, Zwart John-Anker, Cherkas Lynn, Strachan David P, Kubisch Christian, Ferrari Michel D, van den Maagdenberg Arn M J M, Dichgans Martin, Wessman Maija, Smith George Davey, Stefansson Kari, Daly Mark J, Nyholt Dale R, Chasman Daniel, Palotie Aarno. Genome-wide meta-analysis identifies new susceptibility loci for migraine.. Nature genetics. 2013. DOI: 10.1038/ng.2676.
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