Isotretinoin Monitoring Trends: A National Survey of Dermatologists.

<p>

BACKGROUND

Isotretinoin is an effective treatment for nodulocystic acne. Outside of required pregnancy testing, laboratory monitoring suggested by the manufacturers is vague. Dermatologists, therefore, monitor a variety of tests with variable frequency. Despite intense monitoring, the majority of patients do not have gross laboratory abnormalities that warrant changes in management.</p> <p>

OBJECTIVE

To survey US dermatologists regarding laboratory monitoring practices while prescribing isotretinoin.</p> <p>

METHODS

An online survey sent via e-mail to members of the American Academy of Dermatology.</p> <p>

RESULTS

12,396 surveys were sent with a response rate of ~19%. At baseline >60% of responders check a CBC, LFTs, and a lipid panel. 74% check a monthly lipid panel and LFTs, while 57% check a monthly CBC. 75% report stopping isotretinoin when AST or ALT values reach 3 times normal; 89% report stopping at 4 times normal. When triglycerides reach 4 times normal, 72% stop the medication.</p> <p>

CONCLUSIONS

There is no consensus on isotretinoin monitoring tests and frequency, though the majority of dermatologists surveyed monitor a lipid panel and LFTs.</p> <p><em>J Drugs Dermatol. 2017;16(6):557-564.</em></p>.