Consanguineous marriage among familial multiple sclerosis subjects: A national registry-based study.
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Salehi Zahra, Naghizadeh Mohammad Mehdi, Ezabadi Sajjad Ghane, Ebrahimitirtashi Azadeh, Abbasi Kasbi Naghmeh, Khodaie Faezeh, Aliyari Shahram, Ashtari Fereshteh, Baghbanian Seyed Mohammad, Nabavi Seyed Massood, Hosseini Samaneh, Razazian Nazanin, Shaygannejad Vahid, Majdi-Nasab Nastaran, Harirchian Mohammad Hossein, Bayati Asghar, Kamali Hoda, Hosseni Nejad Mir Nahid, Beladi Moghadam Nahid, Poursadeghfard Maryam, Mozhdehipanah Hossein, Jalali Nazanin, Nahayati Mohammad Ali, Faraji Fardin, Kamyari Naser, Sahraian Mohammad Ali, Maghbooli Zhila, Eskandarieh Sharareh
Аннотация
MATERIALS AND METHODS: A cross-sectional study was conducted on clinically definite familial MS (FMS) patients registered in the nationwide MS registry of Iran (NMSRI). Data were extracted and supplemented with structured telephone follow-ups to gather detailed histories of MS in relatives and the familial relationships of the patients' parents. A family penetration score was proposed. Descriptive statistics and inferential statistical tests were used to analyze the data at a significance level of 0.05, adhering to ethical guidelines.
RESULTS: Out of 19,911 individuals registered in the NMSRI, 2307 FMS patients across 13 provinces were included in the final analysis. Among these, 385 (19.3 %) reported parental consanguinity, with 283 (14.2 %) having parents who were cousins and 102 (5.1 %) having parents who were distant relatives. The data showed no significant association between parental kinship and variables such as MS phenotype, number of affected relatives with MS, hospitalization rates, and expanded disability status scale score. Similarly, MS severity did not differ based on parental consanguinity (P-value >0.05). While the rate of consanguineous marriage was higher among patients with an onset age less than 18 years, there was no statistically significant difference in disease onset age based on parental consanguinity status.
CONCLUSION: Our study highlights the complexity of factors influencing MS development, including genetic and environmental components. These results highlight the need for further research to achieve a more comprehensive understanding of MS etiology.