Медицинская библиотека · Journal of medical primatology · 2020

Genotyping of Toxoplasma gondii in a lethal toxoplasmosis outbreak affecting captive howler monkeys (Alouatta sp.).

Santana Clarissa Helena, de Oliveira Ayisa Rodrigues, Dos Santos Daniel O, Pimentel Samantha Pinheiro, de Souza Lucas Dos Reis, Moreira Larissa Giannini Alves, Braz Heloísia Maria Bressan, de Carvalho Thaynara Parente, Lopes Carlos Eduardo Bastos, Oliveira Jefferson Bruno Soares, de Paula Nayara Ferreira, de Carvalho Marcelo Pires Nogueira, Alves Bruna Farias, Pena Hilda Fátima Jesus, Santos Renato Lima

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Аннотация

BACKGROUND

Toxoplasmosis is a zoonotic disease that affects humans and warm-blooded animals. This study describes an outbreak of toxoplasmosis in howler monkeys (Alouatta sp.) and survival of capuchins (Sapajus apella), under the same environmental conditions.

METHODS

Howler monkeys were submitted to post-mortem examination. Tissue samples were processed to histopathology and immunohistochemistry to detect lesions and tachyzoites of Toxoplasma gondii. Tissue samples were also frozen and submitted to PCR and genotyping of T. gondii.

RESULTS

Typical lesions were observed in several organs including the liver, lymph node, and brain, with intralesional cysts and tachyzoites of T. gondii demonstrated by immunohistochemistry. T. gondii genomic sequences were amplified by PCR, and genotyping characterized the same T. gondii clone in all howler monkeys.

CONCLUSIONS

Our results support the notion that some species of neotropical primates are highly susceptible to toxoplasmosis and the hypothesis that capuchins (S. apella) may be resistant.

Для цитирования: Santana Clarissa Helena, de Oliveira Ayisa Rodrigues, Dos Santos Daniel O, Pimentel Samantha Pinheiro, de Souza Lucas Dos Reis, Moreira Larissa Giannini Alves, Braz Heloísia Maria Bressan, de Carvalho Thaynara Parente, Lopes Carlos Eduardo Bastos, Oliveira Jefferson Bruno Soares, de Paula Nayara Ferreira, de Carvalho Marcelo Pires Nogueira, Alves Bruna Farias, Pena Hilda Fátima Jesus, Santos Renato Lima. Genotyping of Toxoplasma gondii in a lethal toxoplasmosis outbreak affecting captive howler monkeys (Alouatta sp.).. Journal of medical primatology. 2020. DOI: 10.1111/jmp.12506.

Предметные рубрики MeSH

Alouatta Animals Animals, Zoo Brazil Female Genotype Male Monkey Diseases Sapajus apella Toxoplasma Toxoplasmosis, Animal

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