Archives of oral biology · 2006
Qualitative effects of dioxin on molars vary among inbred mouse strains.
Сравнительное исследованиеСтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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Keller J M, Huet-Hudson Y M, Leamy L J
Аннотация
OBJECTIVE: We evaluated the effects of different levels of the potent environmental toxicant and teratogen, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), on molar development in mice in six inbred strains, all with TCDD responsive Ahr alleles.
DESIGN: Pregnant females were exposed on gestation day 13 to 4 different levels of TCDD (control, 0.01, 0.1 and 1.0 microg/kg) and their offspring were examined for the frequency of missing third molars (M3s) and for differences in first mandibular molar (M1) cuspal morphology.
RESULTS: Missing M3s were prevalent only in mice in two strains, C3H/HeJ and CBA/J, and their frequency significantly increased with increasing TCDD exposure. The frequency of the M1 variant was high in mice in only one strain, C57BL/10J, and was significantly higher in the treated compared with the control group.
CONCLUSIONS: Inbred mice strains exhibited differential responses to TCDD suggesting that there is a genetic component, beyond Ahr differences, mediating the effects of TCDD on molar development.
DESIGN: Pregnant females were exposed on gestation day 13 to 4 different levels of TCDD (control, 0.01, 0.1 and 1.0 microg/kg) and their offspring were examined for the frequency of missing third molars (M3s) and for differences in first mandibular molar (M1) cuspal morphology.
RESULTS: Missing M3s were prevalent only in mice in two strains, C3H/HeJ and CBA/J, and their frequency significantly increased with increasing TCDD exposure. The frequency of the M1 variant was high in mice in only one strain, C57BL/10J, and was significantly higher in the treated compared with the control group.
CONCLUSIONS: Inbred mice strains exhibited differential responses to TCDD suggesting that there is a genetic component, beyond Ahr differences, mediating the effects of TCDD on molar development.
Предметные рубрики MeSH
AllelesAnimalsAnodontiaBasic Helix-Loop-Helix ProteinsEnvironmental ExposureEnvironmental PollutantsFemaleGestational AgeMaleMiceMice, Inbred AMice, Inbred BALB CMice, Inbred C3HMice, Inbred C57BLMice, Inbred CBAMice, Inbred StrainsMolarMolar, ThirdOdontogenesisPolychlorinated DibenzodioxinsPregnancyPrenatal Exposure Delayed EffectsReceptors, Aryl HydrocarbonTeratogensTooth Crown