Is the local guy, just a local guy?

The most important risk factors and preventive strategies for coronary atherosclerosis are systemic. However, the clinical manifestations of atherosclerotic disease frequently resemble a localized process, instead of a systemic one. In this issue of CCI, Zhang and co-workers described the association between the occurrence of stent failure and the changes in the 3D geometry of coronary segments induced by stent implantation. The investigation of local modulators of coronary disease appears as a large and fertile field of future cardiovascular research.