The Associations Between Depression, Subjective Sleep Quality, and Health-Related Quality of Life in Patients with Meige Syndrome: A Cross-Sectional Study.

OBJECTIVE

This study aimed to assess the health-related quality of life (HRQoL) in patients with Meige syndrome and to explore the associations among socio-demographic factors, depression, sleep quality, and HRQoL.

METHODS

A cross-sectional study was conducted using a convenience sampling method. Data were collected between March and June 2025 from six tertiary hospitals located in Henan Province and Guangdong Province. A total of 376 valid questionnaires were collected. Four instruments were used, including the socio-demographic characteristics questionnaire, the Self-Rating Depression Scale, the Pittsburgh sleep quality index, and the Short-From 36 Health Survey.

RESULTS

The current study reported a mean SF-36 score of 49.6 ± 13.2 among patients with Meige syndrome, indicating moderate HRQoL impairment. The present study identified a negative correlation between HRQoL score with depression score and sleep quality score. Multiple linear regression showed that disease duration (β = 0.17, P < 0.001), self-care ability (β = -0.13, P = 0.013), depression (β = -0.14, P = 0.006) and sleep quality (β = -0.12, P = 0.021) were significant factors associated with HRQoL in Meige syndrome patients.

CONCLUSION

Patients with Meige syndrome exhibited moderate impairment in HRQoL. Depression and poor sleep quality were significantly associated with lower HRQoL.