[Association of single-nucleotide variants of ABCG2 and ABCB1 genes with clinical and laboratory parameters during clozapine therapy].

OBJECTIVE

To evaluate the relationship between low-functioning single-nucleotide variants of rs1045642, rs1128503, and rs2032582 of the ABCB1 gene and rs2231142 of the ABCG2 gene and clinical and laboratory parameters in patients with schizophrenia taking clozapine.

MATERIAL AND

METHODS

The study included 129 patients with paranoid schizophrenia (F20.0, ICD-10) treated with clozapine. Genotyping was performed using a real-time polymerase chain reaction.

RESULTS

Carriers of the rs2231142 minor allele A (CA and AA genotypes) of the ABCG2 gene had significantly higher blood neutrophil counts (p=0.026). There was no significant association between the rs1045642, rs1128503, and rs2032582 polymorphisms of the ABCB1 gene and clinical and laboratory parameters. It can be assumed that an increase in clozapine concentration due to a genetically determined slowing of efflux may contribute to an increased inflammatory response in carriers of minor allele A of the rs2231142 single-nucleotide variant of the ABCG2 gene.

CONCLUSION

Patients with rs2231142 CA and AA genotypes of the ABCG2 gene may require slower clozapine dose titration to reduce the risk of inflammatory reactions.