Entamoeba histolytica in inbred mice: evidence of liver involvement.

Following observations that certain mouse strains appeared to be susceptible to liver invasion by Entamoeba histolytica, mouse strains CBA/HN, CBA/HN, nu/nu, CBA/HN nu/+, CBA/HN Dh/+, CBA/HN +/+, C3H/HeJ Lps/Lps and AB/H, were infected intra-intestinally with strain SAW 408 (zymodeme II) of the amoeba. A number of mice from each group died during the first 14 days with acute lesions. The remainder were killed at 4 and 6 months after infection. CBA/HN, CBA/HN Dh/+, and CBA/HN +/+ mice all had amoeba-infected livers, although only 2 mice had extensive, typical liver lesions.