Медицинская библиотека · Biomarkers in medicine · 2023

GDF-15 and soluble ST2 as biomarkers of right ventricular dysfunction in pulmonary hypertension.

Keranov Stanislav, Widmann Laila, Jafari Leili, Liebetrau Christoph, Keller Till, Troidl Christian, Kriechbaum Steffen, Voss Sandra, Bauer Pascal, Richter Manuel J, Tello Khodr, Gall Henning, Ghofrani Hossein A, Wiedenroth Christoph B, Guth Stefan, Seeger Werner, Hamm Christian W, Nef Holger, Dörr Oliver

СтатьяПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

Background

This study analyzed the utility of soluble ST2 (sST2) and GDF-15 as biomarkers of right ventricular (RV) function in patients with pulmonary hypertension (PH).

Methods

GDF-15 and sST2 serum concentrations were measured in patients with PH (n = 628), dilated cardiomyopathy (n = 31) and left ventricular hypertrophy (n = 47), and in healthy controls (n = 61).

Results

Median sST2 and GDF-15 levels in patients with left ventricular hypertrophy were higher than in patients with PH and dilated cardiomyopathy. In tertile analysis GDF-15 >1363 pg/ml and sST2 >38 ng/ml were associated with higher N-terminal pro-brain natriuretic peptide, RV systolic dysfunction, RV-pulmonary arterial uncoupling and hemodynamic impairment.

Conclusion

GDF-15 and sST2 are potential biomarkers of RV dysfunction in patients with PH.

Для цитирования: Keranov Stanislav, Widmann Laila, Jafari Leili, Liebetrau Christoph, Keller Till, Troidl Christian, Kriechbaum Steffen, Voss Sandra, Bauer Pascal, Richter Manuel J, Tello Khodr, Gall Henning, Ghofrani Hossein A, Wiedenroth Christoph B, Guth Stefan, Seeger Werner, Hamm Christian W, Nef Holger, Dörr Oliver. GDF-15 and soluble ST2 as biomarkers of right ventricular dysfunction in pulmonary hypertension.. Biomarkers in medicine. 2023. DOI: 10.2217/bmm-2022-0395.

Предметные рубрики MeSH

Humans Hypertension, Pulmonary Interleukin-1 Receptor-Like 1 Protein Cardiomyopathy, Dilated Growth Differentiation Factor 15 Hypertrophy, Left Ventricular Ventricular Dysfunction, Right Biomarkers

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