Serum enzyme activity and bilirubin concentration in sheep experimentally infected with Fasciola gigantica.

Fasciola gigantica infection in sheep produced liver and lung lesions characterized by damage to blood vessels and parenchymal necrosis. In the lungs, the lesions were those of parasitic bronchopneumonia. The damage to the liver and lung tissues was accompanied by increased activity in serum of AST after 2 weeks, GD and SD after 4 to 5 weeks and GGT and 5'-NT from 8 weeks onwards. Bilirubin concentration was not affected.