Generation of Carbon and Phosphine Stereocenters via Cobaltaphotoredox-Catalyzed Enantioselective C-H Annulation.

Merging photochemistry with transition-metal-catalyzed asymmetric C-H functionalization represents a highly attractive yet underexplored strategy for the sustainable synthesis of valuable enantiopure molecules. Herein, we report a synergistic catalytic system that combines visible light photoredox catalysis with cobalt catalysis to achieve enantioselective C-H/N-H annulation under mild conditions. The protocol accommodates nine types of alkynes, including internal, terminal, and functionalized derivatives, as well as terminal allenes, providing unified access to carbon- and phosphine-stereogenic N-heterocycles with broad functional group tolerance, high yields, and excellent enantioselectivity.