Dual Nickel/Photoredox-Catalyzed Radical Phosphonylacylation of Terminal Alkenes with Aroyl Chlorides and H-Phosphine Oxides.

We report a dual nickel/photoredox-catalyzed three-component phosphonylacylation of various alkenes using readily accessible substrates and commercially available catalysts, delivering structurally diverse γ-ketophosphine oxides in one pot through concurrent C-P/C-C bond formation. This operationally simple strategy also provides efficient access to natural molecule- and pharmaceutical-containing γ-ketophosphine oxide analogues and features mild reaction conditions, a broad substrate scope, high regioselectivity, and moderate to excellent yields.