[Study of correlation between obstructive sleep apnea-hypopnea syndrome and erythropoietin].

OBJECTIVE

To investigate the effect of uvulopalatopharyngoplasty on change of serum erythropoietin levels in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) treatment.

METHOD: Fifty-nine patients with OSAHS were treated through uvulopalatopharyngoplasty. Observing follow indexes of pre and postoperation: pharyngeal space, neck size. Pre and post-operative serum erythropoietin levels were detected.

RESULT: Neck size, AHI, BMI, SaO2, distance between anterior pillars, distance between uvula and posterior wall, length of palatum, length of uvula and minimum sekar of pharynx oralis in preoperative patients were significant higher than those in postoperative patients (P<0.01). Neck size, BMI and minimum sekar of pharynx oralis in postoperative patients were significant higher than those in normal adults (P<0.01). There were no significant difference between postoperative patients and normal adults in distance between anterior pillars, distance between uvula and posterior wall, length of palatum, length of uvula (P>0.01). The level of EPO in preoperative patients were significant higher than that in postoperative patients (P<0.01). There was no significant difference between postoperative patients and normal adults in the level of EPO (P>0.01).

CONCLUSION

The level of EPO in OSAHS patients is higher than that in normal adults. It was correlative with AHI. The uvulopalatopharyngoplasty was efficacious in treatment of OSAHS. The levels of EPO were decreased through efficacious treatment.