[Change of oxygen free radical in patients with obstructive sleep apnea hypopnea syndrome after the operation of uvulopalatopharyngoplasty].

OBJECTIVE

To explore the mechanism of multiple organ dysfunction in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) by observing the change of SOD,GSH-PX and MDA after uvulopalatopharyngoplasty (UPPP).

METHOD: Colorimetric method was used to examine both the activity of SOD,GSH-PX and the content of MDA before and one month after UPPP in 30 patients with OSAHS. Thirty healthy people were chosen as normal control.

RESULT: Before UPPP, the activity of SOD, GSH-PX and the content of MDA were (106.3 +/- 41.2) nmol/L (compared with the control group, P < 0.05), (61.8 +/- 6.5) kU/L (P < 0.05) and (6.27 +/- 1.73) mmol/L (P < 0.05) respectively; yet after the operation, the results were(128.5 +/- 33.1) nmol/L (compared with the control group, P > 0.05), (64.6 +/- 6.1) kU/L (P > 0.05) and (1.32 +/- 0.58) mmol/L (P > 0.05).

CONCLUSION

The metabolism of oxygen free radical was badly imbalanced in patients with OSAHS, yet one month after UPPP, it was recovered to normal. This suggested that the metabolism imbalance of oxygen free radical was contributed to multiple organ dysfunction in such patients.