Journal of veterinary internal medicine · 2023
Clinical and clinicopathological features and outcomes of cats with suspected dietary induced pancytopenia.
Многоцентровое исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Glanemann Barbara, Humm Karen, Abreu Mariana, Aspinall Sophie, Buckeridge David, Carveth Hope, Darcy Hannah, Florey Jessica, Frowde Polly, Gajanayake Isuru, Green Kate, Holmes Emma, Hrovat Alenka, Jasensky Anne-Katherine, Jones Bryn A, Lantzaki Vasiliki, Lo Eve Jy, MacDonald Kirsty, O'Brien Kevin, Suárez-Bonnet Alejandro, Van den Steen Nele, Szladovits Balazs, Willems Annelies, Wilson Helen
Аннотация
BACKGROUND: After a strong epidemiological link to diet was established in an outbreak of pancytopenia in cats in spring 2021 in the United Kingdom, 3 dry diets were recalled. Concentrations of the hemato- and myelotoxic mycotoxins T-2, HT-2 and diacetoxyscirpenol (DAS) greater than the European Commission guidance for dry cat foods were detected in the recalled diets.
OBJECTIVES: To describe clinical and clinicopathological findings in cats diagnosed with suspected diet induced pancytopenia.
ANIMALS: Fifty cats presenting with pancytopenia after exposure to a recalled diet.
METHODS: Multicenter retrospective case series study. Cats with known exposure to 1 of the recalled diets were included if presented with bi- or pancytopenia and underwent bone marrow examination.
RESULTS: Case fatality rate was 78%. Bone marrow aspirates and biopsy examination results were available in 23 cats; 19 cats had a bone marrow aspirate, and 8 cats had a biopsy core, available for examination. Bone marrow hypo to aplasia-often affecting all cell lines-was the main feature in all 31 available core specimens. A disproportionately pronounced effect on myeloid and megakaryocytic cells was observed in 19 cats. Myelofibrosis or bone marrow necrosis was not a feature.
CONCLUSION AND CLINICAL IMPORTANCE: Mycotoxin induced pancytopenia should be considered as differential diagnosis in otherwise healthy cats presenting with bi- or pancytopenia and bone marrow hypo- to aplasia.
OBJECTIVES: To describe clinical and clinicopathological findings in cats diagnosed with suspected diet induced pancytopenia.
ANIMALS: Fifty cats presenting with pancytopenia after exposure to a recalled diet.
METHODS: Multicenter retrospective case series study. Cats with known exposure to 1 of the recalled diets were included if presented with bi- or pancytopenia and underwent bone marrow examination.
RESULTS: Case fatality rate was 78%. Bone marrow aspirates and biopsy examination results were available in 23 cats; 19 cats had a bone marrow aspirate, and 8 cats had a biopsy core, available for examination. Bone marrow hypo to aplasia-often affecting all cell lines-was the main feature in all 31 available core specimens. A disproportionately pronounced effect on myeloid and megakaryocytic cells was observed in 19 cats. Myelofibrosis or bone marrow necrosis was not a feature.
CONCLUSION AND CLINICAL IMPORTANCE: Mycotoxin induced pancytopenia should be considered as differential diagnosis in otherwise healthy cats presenting with bi- or pancytopenia and bone marrow hypo- to aplasia.