[Suppression of epithelial cell proliferation in mice by splenocytes from unilaterally sialoadenectomized syngeneic donors].

Partially hepatectomized CBA mice immediately after the operation were intra-orbitally injected with splenocytes of intact (I), Sham-operated (SH-0) or unilaterally sialadenectomized (USAE) syngenic donors. It was shown that splenocytes from USAE donors in contrast to their types of splenocytes acutely suppress the mitotic activity of hepatocytes in the regenerating liver 48 and 72 h after their transfer. Splenocytes isolated 17, 144 and 168 h after removal of submandibular (together with sublingual) gland had the biggest inhibiting ability. Similar effect was obtained in respect of corneal epithelium due to administration of USAE mice splenocytes 17, 48 and 72 h after surgery. Operated recipients are more susceptible to the action of splenocytes from USAE donors, than the non-operated ones.