Infection and immunity · 2004
Induction of protection against porcine cysticercosis by vaccination with recombinant oncosphere antigens.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Flisser Ana, Gauci Charles G, Zoli André, Martinez-Ocaña Joel, Garza-Rodriguez Adriana, Dominguez-Alpizar Jose Luis, Maravilla Pablo, Rodriguez-Canul Rossana, Avila Guillermina, Aguilar-Vega Laura, Kyngdon Craig, Geerts Stanny, Lightowlers Marshall W
Аннотация
Two recombinant Taenia solium oncosphere antigens, designated TSOL18 and TSOL45-1A, were investigated as vaccines to prevent transmission of the zoonotic disease cysticercosis through pigs. Both antigens were effective in inducing very high levels of protection (up to 100%) in three independent vaccine trials in pigs against experimental challenge infection with T. solium eggs, which were undertaken in Mexico and Cameroon. This is the highest level of protection that has been achieved against T. solium infection in pigs by vaccination with a defined antigen. TSOL18 and TSOL45-1A provide the basis for development of a highly effective practical vaccine that could assist in the control and, potentially, the eradication of human neurocysticercosis.