Journal of tropical pediatrics · 2016
Assessment of Adequacy of Supplementation of Vitamin D in Very Low Birth Weight Preterm Neonates: A Randomized Controlled Trial.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Mathur N B, Saini Ashish, Mishra T K
Аннотация
OBJECTIVES: To compare the effect of 400 IU and 1000 IU vitamin D for 6 weeks in very low birth weight preterm neonates.
DESIGN: Randomized, double-blinded controlled trial in a teaching hospital.
PARTICIPANTS: Fifty very low birth weight preterm neonates.
INTERVENTION: Vitamin D 400 IU/day (Group 1) or 1000 IU/day (Group 2).
OUTCOME MEASURES: Change in serum calcium, phosphate, alkaline phosphatase (ALP), 25-hydroxy vitamin D (25-OHD), parathormone, incidence of skeletal hypomineralization and growth.
RESULTS: After 6 weeks of supplementation, the mean serum calcium and 25-OHD levels were significantly higher (p < 0.001 each), while ALP and parathormone levels significantly lower (p < 0.001 each) in group 2. Skeletal hypomineralization was lesser and growth better in group 2.
CONCLUSION: Vitamin D supplementation in a dose of 1000 IU/day is more effective in maintaining serum calcium, phosphate, ALP, 25-OHD and parathormone levels with lower incidence of skeletal hypomineralization and better growth.
DESIGN: Randomized, double-blinded controlled trial in a teaching hospital.
PARTICIPANTS: Fifty very low birth weight preterm neonates.
INTERVENTION: Vitamin D 400 IU/day (Group 1) or 1000 IU/day (Group 2).
OUTCOME MEASURES: Change in serum calcium, phosphate, alkaline phosphatase (ALP), 25-hydroxy vitamin D (25-OHD), parathormone, incidence of skeletal hypomineralization and growth.
RESULTS: After 6 weeks of supplementation, the mean serum calcium and 25-OHD levels were significantly higher (p < 0.001 each), while ALP and parathormone levels significantly lower (p < 0.001 each) in group 2. Skeletal hypomineralization was lesser and growth better in group 2.
CONCLUSION: Vitamin D supplementation in a dose of 1000 IU/day is more effective in maintaining serum calcium, phosphate, ALP, 25-OHD and parathormone levels with lower incidence of skeletal hypomineralization and better growth.
Предметные рубрики MeSH
Alkaline PhosphataseCalcifediolCalciumDietary SupplementsDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansIncidenceIndiaInfant, NewbornInfant, PrematureInfant, Premature, DiseasesInfant, Very Low Birth WeightMaleParathyroid HormonePhosphatesPrevalenceVitamin DVitamin D DeficiencyVitamins