Journal of inorganic biochemistry · 2026
Synthesis and evaluation of the combined chemotherapeutic and photodynamic action of new Pt-complexes of natural chlorins.
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Ostroverkhov Petr V, Plutinskaya Anna D, Luneva Ksenia V, Borzhitskaya Evgeniya O, Lavrinova Polina E, Govorov Nikolay D, Golovanov Aleksey B, Neryabova Ekaterina S, Martinov Leonid Y, Usachev Maxim N, Filonenko Elena V, Bezborodova Olga A, Grin Mikhail A
Аннотация
The combination of multiple therapeutic methods or drugs in the treatment of oncological diseases is a well-established strategy commonly referred to as combination therapy. This approach allows to reduce the adverse effects and enhance treatment efficacy by overcoming resistance to one of the agents within the combination. In the present study, novel Pt(II) complexes of natural chlorins bearing carboxyl and pyridine substituents were synthesized as potential agents for combination therapy. The structures of the synthesized complexes were confirmed by various physicochemical methods, including 1H and 13C NMR spectroscopy, mass spectrometry, high-resolution chromatography-mass spectrometry and Fourier-transform infrared (FTIR) spectroscopy. In vitro evaluation of the compounds demonstrated an increase in both photoinduced and dark cytotoxicity of the Pt complexes.