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Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026

Technology-natives and technology-adopters: Age differences in remote cognitive assessment in Alzheimer disease.

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Katteri Samhita, Wilks Hannah, Welhaf Matthew, Aschenbrenner Andrew J, Frank Colleen C, Vila-Castelar Clara, Stout Sarah, Sliwinski Martin J, Benzinger Tammie Ls, Florencia Clarens Ma, Cruchaga Carlos, Daniels Alisha, Day Gregory S, Devenney Emma, Gordon Brian A, Huey Edward D, Ikeuchi Takeshi, Ishiguro Takanobu, Ibanez Laura, Jucker Mathias, Karch Celeste, Levin Johannes, Perrin Richard, Renton Alan, Supnet-Bell Charlene, Weston Philip S J, Xiong Chengjie, Libre-Guerra Jorge, McDade Eric M, Bateman Randall J, Morris John C, Dominantly Inherited Alzheimer Network, Hassenstab Jason

Аннотация

INTRODUCTION: Cognitive changes in the asymptomatic stages of Alzheimer disease (AD) are subtle and difficult to detect using conventional cognitive tests. High-frequency smartphone-based testing may improve sensitivity to these changes, but generational differences in technology use could influence performance. We examined generational differences in cognition using remote, high-frequency smartphone assessments.

METHODS: Older adults (N = 444) from the Knight Alzheimer Disease Research Center and young and middle-aged adults (N = 113) from the Dominantly Inherited Alzheimer Network (DIAN) completed an in-clinic cognitive battery and brief smartphone tests up to four times daily for 7 days. We compared adherence, reliability, practice effects, and correlations with in-clinic measures.

RESULTS: Older adults showed higher adherence than younger participants (78% vs 59%). Younger adults achieved higher reliability with fewer sessions and exhibited much smaller practice effects. Smartphone to in-clinic test correlations were strong in both young-to-middle-aged and older adults.

DISCUSSION: Generational differences have important implications for the design and implementation of smartphone-based cognitive studies.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты