The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
A Critical Review of the CRISPR-Cas Technology in the Detection of SARS-CoV-2 Variants.
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Zhang Jie, Li Juezhuo, Zhou Jiawei, Zhong Jiaye, Xu Yue, Mao Xiaolei, Xu Minghui, Luo Shuyin, Yang Yi, Hu Ruiyao, Liu Dong-Ang, Chen Shiyu, Qiu Yuting, Chen Keyi, Yuan Jinghua, Zhang Xinling, Li Xiaoping
Аннотация
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still going on, and as the epidemic situation continues, the genome of SARS-CoV-2 is also mutating and evolving, resulting in more and more SARS-CoV-2 mutant strains, which have brought serious pressure on the prevention and control of COVID-19. Given that the COVID-19 is still spreading, it is extremely important to rapidly identify SARS-CoV-2 variants by nucleic acid assays. Thus, developing highly sensitive and specific assays that are suitable for field testing, high-throughput, and automation, as well as other diagnostic applications for SARS-CoV-2 variants, is urgently needed. This paper reviews the research progress of novel CRISPR-based diagnostic methods for SARS-CoV-2 variants.