Willingness among adults in the United States to receive a combination influenza and COVID-19 vaccine.

Combination vaccines against influenza and coronavirus disease 2019 (COVID-19) are in development and could soon become available. To examine willingness to receive this type of vaccine, we surveyed a convenience sample of adults ages 45-80 from the United States via an online panel in September 2024 (n = 1,043). Multivariable logistic regression identified correlates of participants' willingness to receive a combination vaccine. Overall, 48.3% of participants were willing to get a combination influenza and COVID-19 vaccine. Participants were more willing to get a combination vaccine if they had received an influenza vaccination in the past year (odds ratio [OR] = 2.72, 95% confidence interval [CI]: 1.61-4.62) or a COVID-19 vaccination in the past year (OR = 4.00, 95% CI: 2.40-6.65). Participants were less willing to get a combination vaccine if they had adequate reading ability (OR = 0.44, 95% CI: 0.23-0.84) or had higher general vaccine hesitancy (OR = 0.83, 95% CI: 0.79-0.87). Among all participants, receiving a combination vaccine was a more preferred approach for future vaccination compared to receiving separate vaccines for influenza and COVID-19 or no vaccines at all. Our findings provide insight into people's willingness to receive a combination influenza and COVID-19 vaccine, which can help guide future public health programs for this type of vaccine.